User blog comment:B214/Volume 22 spoilers/@comment-95.90.227.74-20161018202609

I would put Great red and Ophis to Issei`s Relatives as second Parents or so. As of now Issei has no Bloodrelation or DNA of his Parents because his Body was created by Great Red and so he should have Great Red`s DNA and Blood if iàm not wrong. So 2nd Parents or something like else.