User blog comment:Xhatefate/DxD Updates~/@comment-24409634-20160908081433/@comment-9595671-20160909022637

Despite the origins they were designed and based on, I don't think Trihexa and Great Red have any real connection. They're just too different in certain aspects.

Trihexa has a consciousness via it's core and an instinct, but it's still questionable if the beast has any sentience since Apophis and Azi had to control it. Plus he's bascially a chimera, even if he's part dragon I doubt even Samael's poison would do the beast in.

Great Red we do know has intelligence, and the free will to choose to be completely lazy. While he could destroy everything he probably won't and others with similar roles like Shiva would do it before he'd even consider it.

Essentially, Trihexa is more like a force of nature where Great Red is an individual who controls an aspect in nature.