User blog comment:B214/Volume 22 spoilers/@comment-207.96.205.3-20161013163608/@comment-9595671-20161013170729

I personally think the three are equally as strong, this is why Great Red and Ophis would need to unite to fight him. Shiva implied he might actually be able to destroy Trihexa but at the cost of making so much devestation and destruction that it would be rendered meaningless.

Plus one thing Trihexa lacks compared to Ophis and Great Red seems to be intelligence, it's strong but it doesn't seem to think, it only has instinct and reacts like it's a force of nature that destroys. Ironic considering what it's core's true form looks like implying otherwise.