User blog comment:B214/Question & Answers 5/@comment-74.173.162.168-20150413200706/@comment-74.213.68.208-20150414175836

Well in Vol. 6 after reverting back from JD there is a small scene where Ise does see Ophis along with the Vali team, while Great Red is passing by, hence the image of both the LN and the intro in the anime are a representation of that scene