User blog comment:B214/Volume 22 spoilers/@comment-187.195.231.221-20160727171101/@comment-24.113.252.213-20160728032711

That may very well be true. But I have a feeling that Ophis' interactions with Issei and his girls have left a significant impression on her. After the fiasco with Cao Cao and Shalba, I think Ophis knows that she shouldn't trust strangers, and that Issei will always be someone she can count on. She even declined Crom Cruach's challenge because she promised Issei she wouldn't fight.

If the other Factions do succeed in kidnapping and re-fusing Ophis and Lilith, I bet she'll force her way out of there and return to Issei's side.