User blog comment:B214/High School DxD EX/@comment-24053170-20160113224250/@comment-26865168-20160114163515

Ophis is not actually part of Isse's harem.

Ophis and Great Red are the biological parents to current Isse as he got his body from GR's flesh and Ophis's powers.

Personally I want to pair Ophis with Great Red instead of Isse.