User blog comment:B214/Volume 22 spoilers/@comment-95.90.227.74-20161018202609/@comment-30048084-20161019173402

Great red and Ophis are Ise's Second Parents wow I wonder if they will be invited to all his kids birthdays, Ophis will be easy to get a hold of but Great Red might be a bit hard.

anyway jokes aside Ophis and Great Red cannot qualify as Ise's parents in any form as stated above they only contributed components towards Ise's new body nothing else, they did not give him life(blood parents) and they didn't raise him so they can't qualify as foster parents.

The question that remains for me is if Ise is a real devil or merely a unique being that possesses evil pieces because they were already programmed with his soul inside them. They state that certain beings cannot be reincarnated or the requirements for reincarnation are something that surpasses the devil capabilities. This leaves me with the question how can a being that is technically I guess you can call a "True Dragon Demi God" be reincarnated, I know half gods can be reincarnated but a True Dragon seems a bit of a stretch considering Great Red is a being that surpasses all others with Ophis and Trihexa