User blog comment:B214/Volume 21 info & spoilers/@comment-74.173.162.168-20160420191216/@comment-73.46.6.122-20160420194057

so in all likelihood issei may end up with a pair of twins in his harem. And don't say that ophis isn't part of his harem, because she now has a body to rival rias and akeno and she obvisously cares about him otherwise she wouldn't have helped revived him with great red or try to protect his parents, therefore she is now a qualified harem canindate/member.