User blog comment:Jopjopjop/Volume 20 Spoilers/@comment-26865168-20151203194333

What if Isse fuses with both Ophis and  Great Red?

He has very good compatability with them due to his body made up of Great Red's flesh and Ophis's powers.

I think with the fusion of Heavenly Dragon, Uroboros Dragon and True Dragon they can beat the shit out of 666.