User blog comment:Jopjopjop/Volume 20 Spoilers/@comment-24502975-20150612155943/@comment-24502975-20150612165440

Oh, my bad. Well, the dramatic tone of the preview implies death will be a major plot point here. Some people are worried about Ophis, but I don't think anything will happen to her, even with Lilith around. We're just going to get an insanely sad fight between the two and Ise (especially if Qlippoth attacks Kuou, which in itself could be hype as fuck since Ophis would participate and probably Crom would be nearby) akin to the first Pokemon movie with the clones. The quotes on Ise's parents, on the other hand, signal some sort of impending death.

""I'm truly fortunate""

""I wish to see it just a little longer""

Usually when people talk like that, they're about to die. Or at the very least it worries you as they reflect on "living a fortunate life and wanting to enjoy it a bit longer".