User blog comment:Crimson and Darkness/Volume 25 discussion blog/@comment-32252462-20180405181717

have you guys wonder that samael is equal like 666 because Samael has a powerful curse that is extremely deadly to both Dragons and Dragon possessors alike. The poison can also affect snakes or snake-related beings. Even Ophis and Great Red are not immune to this effect. According to Azazel, Samael is the "Evil Intention" God of the Bible made from his hatred, and his existence alone can not only extinguish Dragons, but it can also affect other beings as well, thus, resulting in it being sealed within the depths of Cocytus. The curse even resides within Samael's blood, allowing others besides Samael to use the curse (usually by infusing it into a weapon).