User blog comment:B214/General Discussion/@comment-29963364-20161028202621/@comment-9595671-20161101131615

If they fought together they wouldn't, but remember how it's implied that Ophis, Great Red and Trihexa's power are all equal in their own ways? Great Red represents creation, Ophis is balance, and Trihexa is destruction. They're like their own Trimurti in a way.

That's why I find only one of them fighting Trihexa could lead to mutual destruction on both sides, it might be the only way to truly stop the beast considering it's regeneration. That's why together they could destroy it safely, because Trihexa would then be facing the equivalent to two of himself instead of one.

If they could have gotten Great Red's aid, I think Ophis and Lilith would have still been able to help out enough to cover the difference if not just a bit harder. Heck, mabe Shiva could have filled in the game. Ultimately, they just couldn't get Great Red and that made their options very hard.