User blog comment:B214/Volume 22 spoilers/@comment-28087053-20170114184806/@comment-26821288-20170123185859

Shiva said himself that he couldn't do anything against Trihexa. He said that only Ophis in her prime and Great Red can actually do something about Trihexa. So, yeah, we know he cannot do anything against Trihexa. It was said multiple times throughout the series, Ophis in her prime, alongside Great Red, are the strongest beings, and second to none. No one can do anything against them. And then Trihexa came, which was in their level of power. Which would make him much stronger than Shiva.