User blog comment:B214/Volume 22 spoilers/@comment-24583889-20160621010300/@comment-9595671-20160714211223

Hmm... that actually brings up a good question, is the limitation just Gods in general or only gods that are important in their mythology's fold and have their power come from their religion's supporters?

Ophis isn't in any fold so that could mean she could take an evil piece, but since she was born in the Dimensional Gap which defies normal logic, that may be enough for her to have the same immunity.