User blog comment:SpookyBoogie27/Light Novel Spoilers/@comment-71.190.146.213-20140207022346/@comment-1359322-20140207043137

Techinically, Ophis didn't really create Khaos Brigade, it's those with evil intention that gathers around Ophis, resulting in the creation of Khaos Brigade.

As to who is stronger between Great Red and Ophis, it's not known. The fans all consider Great Red to be stronger but in actuality, Ishibumi never specified who is stronger between those two. He only specified that Ophis is the Strongest Being. And Great Red is a being that is equal to Ophis.