User blog comment:B214/Volume 22 spoilers/@comment-50.139.232.230-20160923232938/@comment-30048084-20160925192850

Zekram's primary reason for targeting Ise is not only his power as the Seikryuutei but also his influence on the underworld itself but at the same time Zekram is playing with fire in my opinion. Ise being a reincarnated devil, one of the Heavenly Dragons, Oppai Dragon( children's hero) and supports the Satan Faction even if Sirzechs is not physically present puts all of Ise's ideals in conflict with the old Devils ideals and we have seen the results of incurring a Dragon's wrath.