User blog comment:B214/Volume 17 spoilers./@comment-24098614-20140318171834/@comment-1359322-20140320014825

Well that depends on many factors, situations and all. Yes Issei's main focus is on females but imagine if Issei was in a situation like Rias, he found a young boy with skills dying or dead in front of him, do you think Issei would just let the boy die or he'll take pity on the boy and reincarnate him so that the boy has a chance to live his life. Knowing Issei, it's kinda obvious he will make the latter choice to help.