User blog comment:B214/Volume 23 discussion blog/@comment-201.215.165.7-20170514195016/@comment-31137559-20170514202422

Issei isn't immortal. If Issei can die by having his Sacred Gear extracted, then what makes you think no one can kill him? Issei isn't Great Red just because his body is made from a little part of his flesh. Issei isn't Ophis even if he has the Power of Infinity. Issei can be killed like any other person in DxD.