User blog comment:B214/Question and Answers 6/@comment-108.7.149.156-20181109004922/@comment-108.7.149.156-20181110161151

"Samael's venom would affect them greatly"

True but Issei also weaponized samael's venom by putting it in one of the Gogmagog bullets. Why couldn't they do the same thing except on a larger scale and give it to those who are precise shots. They could take them out in scores. It's a dangerous weapon but could easily be used if given to the right weilders.