User blog comment:Jopjopjop/Volume 20 Spoilers/@comment-26865168-20150810175135/@comment-26865730-20150814193127

I don't know about that. It seems that unleashing Ophis's power this once has taken a toll on Issei. Perhaps the effects of "Deification" that he has undergone will allow him to use Infinity drive at a higher power level in the future. But right now I doubt he could put up a fight against 666.