User blog comment:B214/Question & Answers 5/@comment-74.173.162.168-20150413200706/@comment-74.213.68.208-20150414185255

Look, in Vol. 6, LIfe 5: The Great Red, whe go back to Ise's point of view and at the time where he, Vali, and others where there witnesing the apperance of Great Red Ise eye's catches the image of a little girl in gothic lolita clothes, which Vali explains that "that" girl over there is Ophis.

So yes Ise sees Ophis in that part of the novel only, and will see her in the anime as well.