Ophis/Relationships

Issei Hyoudou
She plays a big part in Issei's revival in Volume 12 along with the Great Red because he gave Issei part of his flesh along with a portion of Ophis' powers. She was very interested in Issei in Volume 11 because of the changes that have taken place for Ddraig, and asked the latter whether he wants to be a Heavenly Dragon or an Oppai Dragon and talks about the changes in Ddraig's powers because his color has changed to crimson instead of his normal red. She joins Issei's group because Issei is now a part of her and she wants to be with him forever, which causes the girls to be very angry with him. She cares for Issei quite a bit, although she is a bit clingy.

Due to her actions, it is actually possible that Ophis harbors some sort of emotions towards Issei. This is only implied when the date with Issei and Rias is mentioned, where even Ophis seemed willing to go on a date with Issei. This may even show that she may see the other members of the group as rivals. However, there isn't much to go on with only those factors.

Rassei
Ophis is shown to have a good relationship with Rassei as shown in Volume 13 Extra Life where the two are shown to be playing catch with each other. In fact, Ophis mentioned that she will train Rassei.

Ddraig
Ophis and Ddraig seem to be on friendly terms with each other as shown in Volume 11, Ddraig and Ophis were talking with each other about Issei while Issei was in his dying moments.

Great Red
Ophis hates Great Red because some time after she left the Dimensional Gap, he moved in. Because of this, she decided that she cannot go back home until he has been driven out. Even after he saved the life of herself and Issei, she still wants his neck.