User blog comment:Jopjopjop/Volume 19 Spoilers/@comment-25560094-20150515042036/@comment-1359322-20150515100146

Yes if mastered properly, not only the Annihilation Maker but the Dimension Lost user can be unbeatable as well. Leonardo's subspecies BB is the best example, you think 1 individual can take on the herds of monsters created from his BB.

Also remember, Dulio was able to freeze all the Grim Reapers in Hades' palace instantly. Grim Reapers are also Gods, do you think they are weaker than Vasco.