User blog comment:Crimson and Darkness/Volume 25 discussion blog/@comment-34061653-20180624161240/@comment-28884330-20180625225921

Infinity does not make the user invulnerable against everything, considering Ophis was still affected by a Dragon Slayer such as Samael. Therefore, it can be taken that even infinite beings are still damaged by what would be their " natural weaknesses". For example, dragon slayers for Ophis and dragon slayers and light for Issei. There's also how Ophis let people help her to deal with Great Red, which could be taken as her having a risk of being hurt or dying if she fights, as would be natural with anyone fighting someone in their power league. But this also means that there's a chance Infinity is not immune to anything that the user is not inherently weak to, as Great Red doesn't seem to have anything Ophis is naturally weak against.